Assay Detail

CHEMBL2050040

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity to Mycobacterium tuberculosis CYP142A1 by UV-visible spectrophotometry

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Mycobacterium tuberculosis
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1.

Johnston JB, Singh AA, Clary AA, Chen CK, Hayes PY, Chow S, De Voss JJ, Ortiz de Montellano PR.
Bioorg Med Chem (2012) 20 : 4064 -4081
PubMed 22647881 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	6.80	6.80

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2048319	—	—	1	6.80

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2048319	—	Kd	=	160.0	nM	6.80