Assay Detail
Functional
CHEMBL2050054
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against FLT3-dependent human MV4-11 cells after 72 hrs by MTT assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of the novel potent and selective FLT3 inhibitor 1-{5-[7-(3- morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and its anti-acute myeloid leukemia (AML) activities in vitro and in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 6.54 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2046884 | — | — | 1 | 9.52 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 8.52 |
| CHEMBL2046733 | — | — | 1 | 8.30 |
| CHEMBL2046883 | — | — | 1 | 8.22 |
| CHEMBL2046882 | — | — | 1 | 8.00 |
| CHEMBL2046448 | — | — | 1 | 7.92 |
| CHEMBL2046730 | — | — | 1 | 7.70 |
| CHEMBL2046713 | — | — | 1 | 7.70 |
| CHEMBL2046732 | — | — | 1 | 7.66 |
| CHEMBL2046879 | — | — | 1 | 7.66 |
| CHEMBL2046717 | — | — | 1 | 7.60 |
| CHEMBL2046718 | — | — | 1 | 7.57 |
| CHEMBL124660 | TANDUTINIB | 2.0 | 1 | 7.26 |
| CHEMBL2046716 | — | — | 1 | 6.68 |
| CHEMBL2046880 | — | — | 1 | 6.52 |
| CHEMBL2046731 | — | — | 1 | 6.40 |
| CHEMBL2046711 | — | — | 1 | 6.35 |
| CHEMBL2046719 | — | — | 1 | 6.20 |
| CHEMBL2046723 | — | — | 1 | 6.08 |
| CHEMBL2046704 | — | — | 1 | 5.99 |
| CHEMBL2046703 | — | — | 1 | 5.95 |
| CHEMBL2046708 | — | — | 1 | 5.94 |
| CHEMBL2046699 | — | — | 1 | 5.94 |
| CHEMBL2046726 | — | — | 1 | 5.92 |
| CHEMBL2046702 | — | — | 1 | 5.91 |
| CHEMBL2046727 | — | — | 1 | 5.87 |
| CHEMBL2046712 | — | — | 1 | 5.85 |
| CHEMBL2046709 | — | — | 1 | 5.85 |
| CHEMBL2046705 | — | — | 1 | 5.82 |
| CHEMBL2046707 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2046884 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL535 | SUNITINIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2046733 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2046883 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2046882 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2046448 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2046730 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2046713 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2046732 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2046879 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2046717 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2046718 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL124660 | TANDUTINIB | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL2046716 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2046880 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2046731 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2046711 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL2046719 | — | IC50 | = | 625.0 | nM | 6.20 |
| CHEMBL2046723 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL2046704 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL2046703 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL2046699 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL2046708 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL2046726 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2046702 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL2046727 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL2046712 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2046709 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2046705 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2046707 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2046700 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL2046721 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2046720 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL2046724 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL2046701 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL2046706 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2046722 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL2046710 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL2046881 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2046725 | — | IC50 | = | 9040.0 | nM | 5.04 |
| CHEMBL2046729 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2046728 | — | IC50 | > | 11000.0 | nM | - |
| CHEMBL2046715 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2046714 | — | IC50 | > | 5000.0 | nM | - |