Assay Detail
Functional
CHEMBL2050130
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Antiproliferative activity against human HBL100 after 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HBL-100 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel anticancer bivalent colchicine-tubulizine hybrids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.00 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1063 | DEACETYLCOLCHICINE | — | 1 | 7.35 |
| CHEMBL2047118 | — | — | 1 | 6.22 |
| CHEMBL2047112 | — | — | 1 | 6.16 |
| CHEMBL2047116 | — | — | 1 | 6.16 |
| CHEMBL2047117 | — | — | 1 | 6.00 |
| CHEMBL2047114 | — | — | 1 | 5.79 |
| CHEMBL2047115 | — | — | 1 | 5.73 |
| CHEMBL2047113 | — | — | 1 | 5.59 |
| CHEMBL2047119 | — | — | 1 | 5.53 |
| CHEMBL2047111 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1063 | DEACETYLCOLCHICINE | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2047118 | — | IC50 | = | 599.0 | nM | 6.22 |
| CHEMBL2047112 | — | IC50 | = | 699.0 | nM | 6.16 |
| CHEMBL2047116 | — | IC50 | = | 687.0 | nM | 6.16 |
| CHEMBL2047117 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL2047114 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL2047115 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL2047113 | — | IC50 | = | 2590.0 | nM | 5.59 |
| CHEMBL2047119 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL2047111 | — | IC50 | = | 3140.0 | nM | 5.50 |