Assay Detail
Binding
CHEMBL2050140
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Binding affinity to VAChT
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of in vitro bioactivity for vesicular acetylcholine transporter inhibitors containing two carbonyl groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 9.96 | 10.26 |
| IC50 | 1 | 7.47 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87379 | BENZOVESAMICOL | — | 1 | 10.26 |
| CHEMBL129530 | — | — | 1 | 9.66 |
| CHEMBL172975 | — | — | 1 | 7.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87379 | BENZOVESAMICOL | Ki | = | 0.055 | nM | 10.26 |
| CHEMBL129530 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL172975 | — | IC50 | = | 34.0 | nM | 7.47 |