Assay Detail
Binding
CHEMBL2050306
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli thymidylate synthase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.06 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422395 | — | — | 1 | 7.72 |
| CHEMBL225071 | RALTITREXED | 4.0 | 1 | 5.64 |
| CHEMBL225072 | PEMETREXED | 4.0 | 1 | 4.82 |
| CHEMBL2047245 | — | — | 1 | - |
| CHEMBL2047247 | — | — | 1 | - |
| CHEMBL2047248 | — | — | 1 | - |
| CHEMBL2047252 | — | — | 1 | - |
| CHEMBL2047253 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422395 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL225071 | RALTITREXED | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL225072 | PEMETREXED | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2047245 | — | IC50 | > | 14000.0 | nM | - |
| CHEMBL2047247 | — | IC50 | > | 14000.0 | nM | - |
| CHEMBL2047248 | — | IC50 | > | 12000.0 | nM | - |
| CHEMBL2047252 | — | IC50 | > | 13000.0 | nM | - |
| CHEMBL2047253 | — | IC50 | > | 13000.0 | nM | - |