Assay Detail
Binding
CHEMBL2050665
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Binding affinity to wild type HIV1 reverse transcriptase by pre-steady state kinetics study
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Pre-steady state kinetic analysis of cyclobutyl derivatives of 2'-deoxyadenosine 5'-triphosphate as inhibitors of HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 4.87 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL335538 | — | — | 1 | 5.34 |
| CHEMBL2047559 | — | — | 1 | 5.19 |
| CHEMBL1236349 | — | — | 1 | 4.78 |
| CHEMBL2047557 | — | — | 1 | 4.69 |
| CHEMBL2047560 | — | — | 1 | 4.65 |
| CHEMBL2047558 | — | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL335538 | — | Kd | = | 4600.0 | nM | 5.34 |
| CHEMBL2047559 | — | Kd | = | 6500.0 | nM | 5.19 |
| CHEMBL1236349 | — | Kd | = | 16500.0 | nM | 4.78 |
| CHEMBL2047557 | — | Kd | = | 20400.0 | nM | 4.69 |
| CHEMBL2047560 | — | Kd | = | 22400.0 | nM | 4.65 |
| CHEMBL2047558 | — | Kd | = | 25500.0 | nM | 4.59 |