Assay Detail
Functional
CHEMBL2050752
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Growth inhibition of human A549 cells after 48 hrs by SRB assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A-ring dihalogenation increases the cellular activity of combretastatin-templated tetrazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.00 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2047849 | — | — | 1 | 8.55 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.10 |
| CHEMBL2047848 | — | — | 1 | 7.68 |
| CHEMBL2047847 | — | — | 1 | 7.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2047849 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL2047848 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2047847 | — | IC50 | = | 22.0 | nM | 7.66 |