Assay Detail
Binding
CHEMBL2050778
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]noradrenaline uptake at human NET expressed in CHO cells after 10 mins by scintillation counting
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.52 | 7.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1818442 | AMITIFADINE HYDROCHLORIDE | 2.0 | 1 | 7.15 |
| CHEMBL2047574 | — | — | 1 | 6.75 |
| CHEMBL2047573 | — | — | 1 | 6.58 |
| CHEMBL2047561 | — | — | 1 | 6.49 |
| CHEMBL2047570 | — | — | 1 | 6.42 |
| CHEMBL2047571 | — | — | 1 | 6.38 |
| CHEMBL2047580 | — | — | 1 | 6.28 |
| CHEMBL2047572 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1818442 | AMITIFADINE HYDROCHLORIDE | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL2047574 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL2047573 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL2047561 | — | IC50 | = | 327.0 | nM | 6.49 |
| CHEMBL2047570 | — | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL2047571 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL2047580 | — | IC50 | = | 531.0 | nM | 6.28 |
| CHEMBL2047572 | — | IC50 | = | 800.0 | nM | 6.10 |