Assay Detail
Binding
CHEMBL2050841
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Displacement of [3H]AMPA from AMPA receptor in rat cortical synaptical membrane
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: molecular modeling and pharmacological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.05 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222519 | NBQX | — | 1 | 7.16 |
| CHEMBL2047401 | — | — | 1 | 7.10 |
| CHEMBL2047398 | — | — | 1 | 6.58 |
| CHEMBL2047404 | — | — | 1 | 6.34 |
| CHEMBL2047403 | — | — | 1 | 6.14 |
| CHEMBL432748 | — | — | 1 | 5.89 |
| CHEMBL2047397 | — | — | 1 | 5.32 |
| CHEMBL2047399 | — | — | 1 | 5.21 |
| CHEMBL2047405 | — | — | 1 | 4.70 |
| CHEMBL2047402 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222519 | NBQX | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL2047401 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL2047398 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL2047404 | — | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL2047403 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL432748 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL2047397 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL2047399 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL2047405 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL2047402 | — | Ki | = | 126000.0 | nM | - |