Assay Detail
Binding
CHEMBL2050845
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]kainate from high affinity kainate receptor in rat cortical membrane
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: molecular modeling and pharmacological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.91 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2047401 | — | — | 1 | 5.52 |
| CHEMBL2047403 | — | — | 1 | 5.38 |
| CHEMBL2047398 | — | — | 1 | 5.16 |
| CHEMBL222519 | NBQX | — | 1 | 5.16 |
| CHEMBL2047404 | — | — | 1 | 4.76 |
| CHEMBL432748 | — | — | 1 | 4.72 |
| CHEMBL2047400 | — | — | 1 | 4.60 |
| CHEMBL2047399 | — | — | 1 | 4.50 |
| CHEMBL2047397 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2047401 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2047403 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL2047398 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL222519 | NBQX | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2047404 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL432748 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL2047400 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL2047399 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL2047397 | — | IC50 | = | 37600.0 | nM | 4.42 |