Assay Detail
Functional
CHEMBL2050848
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Antagonist activity at NMDA receptor in mouse cortical wedge assessed as inhibition of NMDA-induced membrane depolarization by electrophysiological assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: molecular modeling and pharmacological studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.04 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50267 | — | — | 1 | 5.33 |
| CHEMBL2047403 | — | — | 1 | 5.16 |
| CHEMBL2047401 | — | — | 1 | 4.62 |
| CHEMBL2047397 | — | — | 1 | - |
| CHEMBL2047404 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50267 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL2047403 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2047401 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL2047397 | — | IC50 | - | — | - | |
| CHEMBL2047404 | — | IC50 | > | 50000.0 | nM | - |