Assay Detail
Functional
CHEMBL2050951
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Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.21 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1554 | DACTINOMYCIN | 4.0 | 1 | 8.14 |
| CHEMBL2047418 | — | — | 1 | 5.82 |
| CHEMBL2047413 | — | — | 1 | 5.58 |
| CHEMBL2047411 | WITHARISTATIN | — | 1 | 5.38 |
| CHEMBL2047419 | — | — | 1 | 5.28 |
| CHEMBL517080 | WITHAFERIN A | 1.0 | 1 | 5.18 |
| CHEMBL2047407 | — | — | 1 | 5.17 |
| CHEMBL2047410 | — | — | 1 | 5.05 |
| CHEMBL2047417 | — | — | 1 | 4.83 |
| CHEMBL2047409 | — | — | 1 | 4.74 |
| CHEMBL2047415 | — | — | 1 | 4.59 |
| CHEMBL1934585 | — | — | 1 | 4.47 |
| CHEMBL2047412 | — | — | 1 | 4.40 |
| CHEMBL1425 | MERCAPTOPURINE ANHYDROUS | 4.0 | 1 | 4.33 |
| CHEMBL2047406 | — | — | 1 | - |
| CHEMBL2047416 | — | — | 1 | - |
| CHEMBL2047414 | — | — | 1 | - |
| CHEMBL2047408 | — | — | 1 | - |
| CHEMBL2047420 | — | — | 1 | - |
| CHEMBL2047421 | — | — | 1 | - |
| CHEMBL2047422 | — | — | 1 | - |
| CHEMBL2047423 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1554 | DACTINOMYCIN | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL2047418 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2047413 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL2047411 | WITHARISTATIN | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL2047419 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL517080 | WITHAFERIN A | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL2047407 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL2047410 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL2047417 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL2047409 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL2047415 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL1934585 | — | IC50 | = | 33500.0 | nM | 4.47 |
| CHEMBL2047412 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL1425 | MERCAPTOPURINE ANHYDROUS | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL2047406 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2047416 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2047414 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2047408 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2047420 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2047421 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2047422 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2047423 | — | IC50 | > | 40000.0 | nM | - |