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Assay Detail

CHEMBL2050952

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells.
Llanos GG, Araujo LM, Jiménez IA, Moujir LM, Bazzocchi IL.
Eur J Med Chem (2012) 54 : 499 -511
PubMed 22705001 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.13 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2047418 1 6.00
CHEMBL2047419 1 5.68
CHEMBL517080 WITHAFERIN A 1.0 1 5.64
CHEMBL2047411 WITHARISTATIN 1 5.57
CHEMBL2047413 1 5.54
CHEMBL2047410 1 5.47
CHEMBL2047407 1 5.33
CHEMBL2047412 1 5.10
CHEMBL2047409 1 5.08
CHEMBL2047417 1 4.92
CHEMBL2047415 1 4.82
CHEMBL1934585 1 4.71
CHEMBL2047414 1 4.70
CHEMBL2047406 1 4.51
CHEMBL2047416 1 4.50
CHEMBL2047408 1 4.43
CHEMBL2047420 1 -
CHEMBL2047421 1 -
CHEMBL2047422 1 -
CHEMBL2047423 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2047418 IC50 = 1000.0 nM 6.00
CHEMBL2047419 IC50 = 2100.0 nM 5.68
CHEMBL517080 WITHAFERIN A IC50 = 2300.0 nM 5.64
CHEMBL2047411 WITHARISTATIN IC50 = 2700.0 nM 5.57
CHEMBL2047413 IC50 = 2900.0 nM 5.54
CHEMBL2047410 IC50 = 3400.0 nM 5.47
CHEMBL2047407 IC50 = 4700.0 nM 5.33
CHEMBL2047412 IC50 = 8000.0 nM 5.10
CHEMBL2047409 IC50 = 8300.0 nM 5.08
CHEMBL2047417 IC50 = 12100.0 nM 4.92
CHEMBL2047415 IC50 = 15200.0 nM 4.82
CHEMBL1934585 IC50 = 19300.0 nM 4.71
CHEMBL2047414 IC50 = 19800.0 nM 4.70
CHEMBL2047406 IC50 = 31100.0 nM 4.51
CHEMBL2047416 IC50 = 31400.0 nM 4.50
CHEMBL2047408 IC50 = 37300.0 nM 4.43
CHEMBL2047420 IC50 > 40000.0 nM -
CHEMBL2047421 IC50 > 40000.0 nM -
CHEMBL2047422 IC50 > 40000.0 nM -
CHEMBL2047423 IC50 > 40000.0 nM -