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Assay Detail

CHEMBL2051050

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Binding
Inhibition of CK2
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovery and structure-activity relationship of 2,6-disubstituted pyrazines, potent and selective inhibitors of protein kinase CK2.
Fuchi N, Iura Y, Kaneko H, Nitta A, Suyama K, Ueda H, Yamaguchi S, Nishimura K, Fujii S, Sekiya Y, Yamada M, Takahashi T.
Bioorg Med Chem Lett (2012) 22 : 4358 -4361
PubMed 22633690 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 7.20 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2048140 1 8.10
CHEMBL1231683 1 8.10
CHEMBL2048144 1 8.03
CHEMBL2048139 1 7.92
CHEMBL2048142 1 7.80
CHEMBL2048143 1 7.66
CHEMBL2048141 1 7.60
CHEMBL2048138 1 7.52
CHEMBL2048137 1 7.30
CHEMBL92361 1 7.10
CHEMBL2048135 1 7.00
CHEMBL2048136 1 7.00
CHEMBL2048132 1 6.52
CHEMBL2048133 1 6.30
CHEMBL289277 EMODIN 1 5.70
CHEMBL2048134 1 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2048140 IC50 = 8.0 nM 8.10
CHEMBL1231683 IC50 = 8.0 nM 8.10
CHEMBL2048144 IC50 = 9.3 nM 8.03
CHEMBL2048139 IC50 = 12.0 nM 7.92
CHEMBL2048142 IC50 = 16.0 nM 7.80
CHEMBL2048143 IC50 = 22.0 nM 7.66
CHEMBL2048141 IC50 = 25.0 nM 7.60
CHEMBL2048138 IC50 = 30.0 nM 7.52
CHEMBL2048137 IC50 = 50.0 nM 7.30
CHEMBL92361 IC50 = 80.0 nM 7.10
CHEMBL2048135 IC50 = 100.0 nM 7.00
CHEMBL2048136 IC50 = 100.0 nM 7.00
CHEMBL2048132 IC50 = 300.0 nM 6.52
CHEMBL2048133 IC50 = 500.0 nM 6.30
CHEMBL289277 EMODIN IC50 = 2000.0 nM 5.70
CHEMBL2048134 IC50 = 3000.0 nM 5.52