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Assay Detail

CHEMBL2051272

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec using phenol red indicator-based stopped flow assay
ChEMBL ↗
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 2 (CHEMBL205) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines.
Winum JY, Carta F, Ward C, Mullen P, Harrison D, Langdon SP, Cecchi A, Scozzafava A, Kunkler I, Supuran CT.
Bioorg Med Chem Lett (2012) 22 : 4681 -4685
PubMed 22721713 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 50 6.44 6.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2047820 — — 1 6.92
CHEMBL2047805 — — 1 6.84
CHEMBL2047800 — — 1 6.73
CHEMBL2047819 — — 1 6.72
CHEMBL2047807 — — 1 6.67
CHEMBL2047841 — — 1 6.63
CHEMBL2047843 — — 1 6.59
CHEMBL2047801 — — 1 6.55
CHEMBL2047803 — — 1 6.55
CHEMBL2047818 — — 1 6.55
CHEMBL2047798 — — 1 6.54
CHEMBL2047806 — — 1 6.54
CHEMBL2047810 — — 1 6.54
CHEMBL2047826 — — 1 6.54
CHEMBL2047797 — — 1 6.54
CHEMBL2047817 — — 1 6.54
CHEMBL2047813 — — 1 6.53
CHEMBL2047799 — — 1 6.52
CHEMBL2047829 — — 1 6.51
CHEMBL2047837 — — 1 6.51
CHEMBL2047840 — — 1 6.50
CHEMBL2047804 — — 1 6.50
CHEMBL2047815 — — 1 6.47
CHEMBL2047834 — — 1 6.46
CHEMBL2047809 — — 1 6.46
CHEMBL2047827 — — 1 6.46
CHEMBL2047824 — — 1 6.46
CHEMBL2047796 — — 1 6.41
CHEMBL2047802 — — 1 6.38
CHEMBL2047825 — — 1 6.38

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2047820 — Ki = 119.0 nM 6.92
CHEMBL2047805 — Ki = 145.0 nM 6.84
CHEMBL2047800 — Ki = 186.0 nM 6.73
CHEMBL2047819 — Ki = 192.0 nM 6.72
CHEMBL2047807 — Ki = 213.0 nM 6.67
CHEMBL2047841 — Ki = 236.0 nM 6.63
CHEMBL2047843 — Ki = 257.0 nM 6.59
CHEMBL2047801 — Ki = 279.0 nM 6.55
CHEMBL2047803 — Ki = 284.0 nM 6.55
CHEMBL2047818 — Ki = 280.0 nM 6.55
CHEMBL2047810 — Ki = 286.0 nM 6.54
CHEMBL2047798 — Ki = 291.0 nM 6.54
CHEMBL2047806 — Ki = 286.0 nM 6.54
CHEMBL2047817 — Ki = 285.0 nM 6.54
CHEMBL2047826 — Ki = 285.0 nM 6.54
CHEMBL2047797 — Ki = 287.0 nM 6.54
CHEMBL2047813 — Ki = 298.0 nM 6.53
CHEMBL2047799 — Ki = 305.0 nM 6.52
CHEMBL2047829 — Ki = 310.0 nM 6.51
CHEMBL2047837 — Ki = 306.0 nM 6.51
CHEMBL2047804 — Ki = 319.0 nM 6.50
CHEMBL2047840 — Ki = 317.0 nM 6.50
CHEMBL2047815 — Ki = 338.0 nM 6.47
CHEMBL2047824 — Ki = 348.0 nM 6.46
CHEMBL2047827 — Ki = 347.0 nM 6.46
CHEMBL2047834 — Ki = 344.0 nM 6.46
CHEMBL2047809 — Ki = 348.0 nM 6.46
CHEMBL2047796 — Ki = 393.0 nM 6.41
CHEMBL2047802 — Ki = 413.0 nM 6.38
CHEMBL2047825 — Ki = 413.0 nM 6.38
CHEMBL2047844 — Ki = 421.0 nM 6.38
CHEMBL2047812 — Ki = 431.0 nM 6.37
CHEMBL2047842 — Ki = 438.0 nM 6.36
CHEMBL2047836 — Ki = 435.0 nM 6.36
CHEMBL2047838 — Ki = 448.0 nM 6.35
CHEMBL2047845 — Ki = 443.0 nM 6.35
CHEMBL2047808 — Ki = 450.0 nM 6.35
CHEMBL2047830 — Ki = 459.0 nM 6.34
CHEMBL2047816 — Ki = 467.0 nM 6.33
CHEMBL2047828 — Ki = 486.0 nM 6.31
CHEMBL2047839 — Ki = 541.0 nM 6.27
CHEMBL2047832 — Ki = 547.0 nM 6.26
CHEMBL2047811 — Ki = 546.0 nM 6.26
CHEMBL2047835 — Ki = 568.0 nM 6.25
CHEMBL2047831 — Ki = 613.0 nM 6.21
CHEMBL2047814 — Ki = 641.0 nM 6.19
CHEMBL2047833 — Ki = 750.0 nM 6.12
CHEMBL2047821 — Ki = 761.0 nM 6.12
CHEMBL2047822 — Ki = 815.0 nM 6.09
CHEMBL2047823 — Ki = 902.0 nM 6.04