Assay Detail
Binding
CHEMBL2051552
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 3-[4-({2',6'-dimethyl-6-[(4-[3H])phenylmethoxy]biphenyl-3-yl}methoxy)phenyl] propanoic acid from human GPR40 receptor expressed in CHO cell membrane after 90 mins by liquid scintillation counting in the presence of 0.2% BSA
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of phenylpropanoic acid derivatives containing polar functionalities as potent and orally bioavailable G protein-coupled receptor 40 agonists for the treatment of type 2 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.57 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2048620 | — | — | 1 | 7.92 |
| CHEMBL2048618 | — | — | 1 | 7.92 |
| CHEMBL2048616 | — | — | 1 | 7.82 |
| CHEMBL2048622 | — | — | 1 | 7.82 |
| CHEMBL2048615 | — | — | 1 | 7.80 |
| CHEMBL2048623 | — | — | 1 | 7.80 |
| CHEMBL2048628 | — | — | 1 | 7.75 |
| CHEMBL2048626 | — | — | 1 | 7.75 |
| CHEMBL2048627 | — | — | 1 | 7.72 |
| CHEMBL2048624 | — | — | 1 | 7.72 |
| CHEMBL2048625 | — | — | 1 | 7.70 |
| CHEMBL2048619 | — | — | 1 | 7.70 |
| CHEMBL2048621 | — | — | 1 | 7.68 |
| CHEMBL2048617 | — | — | 1 | 7.64 |
| CHEMBL2048614 | — | — | 1 | 7.60 |
| CHEMBL1688473 | — | — | 1 | 7.50 |
| CHEMBL1688486 | — | — | 1 | 7.34 |
| CHEMBL2048613 | — | — | 1 | 7.33 |
| CHEMBL2048610 | — | — | 1 | 7.24 |
| CHEMBL2048612 | — | — | 1 | 7.00 |
| CHEMBL2048611 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2048620 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL2048618 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL2048616 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL2048622 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL2048615 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL2048623 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL2048628 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL2048626 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL2048627 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL2048624 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL2048625 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL2048619 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL2048621 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL2048617 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL2048614 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL1688473 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL1688486 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL2048613 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL2048610 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL2048612 | — | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL2048611 | — | Ki | = | 520.0 | nM | 6.28 |