Assay Detail
Binding
CHEMBL2051643
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Inhibition of human purified renin
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 8.42 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2048703 | — | — | 1 | 9.00 |
| CHEMBL2048702 | — | — | 1 | 9.00 |
| CHEMBL2048704 | — | — | 1 | 9.00 |
| CHEMBL2048564 | — | — | 1 | 8.92 |
| CHEMBL2048706 | — | — | 1 | 8.85 |
| CHEMBL2046465 | — | — | 1 | 8.85 |
| CHEMBL2048571 | — | — | 1 | 8.85 |
| CHEMBL2048566 | — | — | 1 | 8.77 |
| CHEMBL2048570 | — | — | 1 | 8.77 |
| CHEMBL2048707 | — | — | 1 | 8.72 |
| CHEMBL2048567 | — | — | 1 | 8.72 |
| CHEMBL2048705 | — | — | 1 | 8.70 |
| CHEMBL2048576 | — | — | 1 | 8.70 |
| CHEMBL2048575 | — | — | 1 | 8.70 |
| CHEMBL2048579 | — | — | 1 | 8.68 |
| CHEMBL2048574 | — | — | 1 | 8.68 |
| CHEMBL2048580 | — | — | 1 | 8.68 |
| CHEMBL2048569 | — | — | 1 | 8.66 |
| CHEMBL2048701 | — | — | 1 | 8.62 |
| CHEMBL2048577 | — | — | 1 | 8.62 |
| CHEMBL2048573 | — | — | 1 | 8.52 |
| CHEMBL2048568 | — | — | 1 | 8.51 |
| CHEMBL2048563 | — | — | 1 | 8.48 |
| CHEMBL2048572 | — | — | 1 | 8.38 |
| CHEMBL2048578 | — | — | 1 | 8.26 |
| CHEMBL2048561 | — | — | 1 | 6.89 |
| CHEMBL2048565 | — | — | 1 | 6.77 |
| CHEMBL2048560 | — | — | 1 | 6.43 |
| CHEMBL2048562 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2048703 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2048702 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2048704 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2048564 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL2048706 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2046465 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2048571 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL2048566 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL2048570 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL2048707 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL2048567 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL2048705 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2048576 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2048575 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2048579 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL2048574 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL2048580 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL2048569 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL2048701 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL2048577 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL2048573 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2048568 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL2048563 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL2048572 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL2048578 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL2048561 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2048565 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2048560 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL2048562 | — | IC50 | = | 400.0 | nM | 6.40 |