Assay Detail
Binding
CHEMBL2051644
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Inhibition of renin in cynomolgus monkey plasma
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Macaca fascicularis |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and optimization of novel (2S,4S,5S)-5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxy-2-isopropylhexanamides as renin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.51 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2048703 | — | — | 1 | 8.70 |
| CHEMBL2048707 | — | — | 1 | 8.30 |
| CHEMBL2048564 | — | — | 1 | 8.28 |
| CHEMBL2046465 | — | — | 1 | 8.19 |
| CHEMBL2048579 | — | — | 1 | 8.15 |
| CHEMBL2048571 | — | — | 1 | 8.15 |
| CHEMBL2048706 | — | — | 1 | 8.10 |
| CHEMBL2048702 | — | — | 1 | 8.05 |
| CHEMBL2048566 | — | — | 1 | 8.01 |
| CHEMBL2048563 | — | — | 1 | 8.00 |
| CHEMBL2048704 | — | — | 1 | 7.96 |
| CHEMBL2048575 | — | — | 1 | 7.96 |
| CHEMBL2048577 | — | — | 1 | 7.92 |
| CHEMBL2048567 | — | — | 1 | 7.72 |
| CHEMBL2048573 | — | — | 1 | 7.64 |
| CHEMBL2048570 | — | — | 1 | 7.62 |
| CHEMBL2048574 | — | — | 1 | 7.60 |
| CHEMBL2048705 | — | — | 1 | 7.60 |
| CHEMBL2048580 | — | — | 1 | 7.55 |
| CHEMBL2048576 | — | — | 1 | 7.52 |
| CHEMBL2048569 | — | — | 1 | 7.52 |
| CHEMBL2048701 | — | — | 1 | 7.48 |
| CHEMBL2048568 | — | — | 1 | 7.31 |
| CHEMBL2048572 | — | — | 1 | 7.24 |
| CHEMBL2048578 | — | — | 1 | 7.05 |
| CHEMBL2048565 | — | — | 1 | 6.06 |
| CHEMBL2048561 | — | — | 1 | 5.55 |
| CHEMBL2048562 | — | — | 1 | 5.52 |
| CHEMBL2048560 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2048703 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2048707 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2048564 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL2046465 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL2048579 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2048571 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2048706 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2048702 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2048566 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL2048563 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2048704 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2048575 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2048577 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2048567 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2048573 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL2048570 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL2048574 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2048705 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2048580 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2048576 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2048569 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2048701 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2048568 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL2048572 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL2048578 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2048565 | — | IC50 | = | 875.0 | nM | 6.06 |
| CHEMBL2048561 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2048562 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2048560 | — | IC50 | = | 12500.0 | nM | 4.90 |