Assay Detail
Binding
CHEMBL2051658
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Binding affinity to bovine brain tubulin by spectrophotometric analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.59 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2024561 | — | — | 1 | 7.19 |
| CHEMBL2048720 | — | — | 1 | 7.14 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.55 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2024561 | — | Kd | = | 65.0 | nM | 7.19 |
| CHEMBL2048720 | — | Kd | = | 72.0 | nM | 7.14 |
| CHEMBL67 | COMBRETASTATIN A4 | Kd | = | 280.0 | nM | 6.55 |
| CHEMBL107 | COLCHICINE | Kd | = | 3300.0 | nM | 5.48 |