Assay Detail
Functional
CHEMBL2051659
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Cytotoxicity against human HT-29 cells after 48 hrs by XTT assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.46 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2048720 | — | — | 1 | 9.30 |
| CHEMBL2048719 | — | — | 1 | 9.22 |
| CHEMBL2048723 | — | — | 1 | 8.96 |
| CHEMBL2048722 | — | — | 1 | 8.70 |
| CHEMBL2048718 | — | — | 1 | 8.52 |
| CHEMBL2048713 | — | — | 1 | 8.42 |
| CHEMBL2048724 | — | — | 1 | 8.40 |
| CHEMBL2048721 | — | — | 1 | 8.22 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.03 |
| CHEMBL2048712 | — | — | 1 | 7.41 |
| CHEMBL2048709 | — | — | 1 | 7.39 |
| CHEMBL2048725 | — | — | 1 | 6.83 |
| CHEMBL2048711 | — | — | 1 | 6.44 |
| CHEMBL2048714 | — | — | 1 | 6.02 |
| CHEMBL2048708 | — | — | 1 | 5.92 |
| CHEMBL2048715 | — | — | 1 | 5.75 |
| CHEMBL2048717 | — | — | 1 | 5.60 |
| CHEMBL2048716 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2048720 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL2048719 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL2048723 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL2048722 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2048718 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL2048713 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL2048724 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2048721 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL107 | COLCHICINE | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL2048712 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL2048709 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2048725 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL2048711 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2048714 | — | IC50 | = | 955.0 | nM | 6.02 |
| CHEMBL2048708 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2048715 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL2048717 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2048716 | — | IC50 | = | 7300.0 | nM | 5.14 |