Assay Detail
Functional
CHEMBL2051660
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Cytotoxicity against human HeLa cells after 48 hrs by WST-8 assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of benzophenone-bearing diketopiperazine-type anti-microtubule agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.44 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2048720 | — | — | 1 | 8.77 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.66 |
| CHEMBL2024561 | — | — | 1 | 8.64 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2048720 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL2024561 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL107 | COLCHICINE | IC50 | = | 20.2 | nM | 7.70 |