Assay Detail
Functional
CHEMBL2051671
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Antiproliferative activity against human MOLT3 cells expressing FLT3 gene
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLT-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
An amino-indazole scaffold with spectrum selective kinase inhibition of FLT3, PDGFRα and kit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.23 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2048736 | — | — | 1 | 8.70 |
| CHEMBL2048845 | — | — | 1 | 8.70 |
| CHEMBL2048742 | — | — | 1 | 8.40 |
| CHEMBL2048729 | — | — | 1 | 8.30 |
| CHEMBL2048735 | — | — | 1 | 8.30 |
| CHEMBL2048741 | — | — | 1 | 7.48 |
| CHEMBL2048739 | — | — | 1 | 7.46 |
| CHEMBL2048730 | — | — | 1 | 6.49 |
| CHEMBL2048737 | — | — | 1 | 6.25 |
| CHEMBL2048731 | — | — | 1 | 5.77 |
| CHEMBL2048738 | — | — | 1 | 5.46 |
| CHEMBL2048734 | — | — | 1 | 5.43 |
| CHEMBL2048732 | — | — | 1 | - |
| CHEMBL2048733 | — | — | 1 | - |
| CHEMBL2048740 | — | — | 1 | - |
| CHEMBL2048743 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2048736 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2048845 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2048742 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2048729 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2048735 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2048741 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL2048739 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2048730 | — | EC50 | = | 325.0 | nM | 6.49 |
| CHEMBL2048737 | — | EC50 | = | 559.0 | nM | 6.25 |
| CHEMBL2048731 | — | EC50 | = | 1713.0 | nM | 5.77 |
| CHEMBL2048738 | — | EC50 | = | 3426.0 | nM | 5.46 |
| CHEMBL2048734 | — | EC50 | = | 3752.0 | nM | 5.43 |
| CHEMBL2048732 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2048733 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL2048740 | — | EC50 | < | 1.0 | nM | - |
| CHEMBL2048743 | — | EC50 | < | 1.0 | nM | - |