Assay Detail
Binding
CHEMBL2051700
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Inhibition of human recombinant HDAC2 after 30 mins by fluorometric assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.44 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 8.77 |
| CHEMBL2048750 | — | — | 1 | 8.64 |
| CHEMBL2048746 | — | — | 1 | 8.40 |
| CHEMBL2048752 | — | — | 1 | 6.72 |
| CHEMBL2048751 | — | — | 1 | 6.70 |
| CHEMBL2048749 | — | — | 1 | 6.44 |
| CHEMBL2048755 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL2048750 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL2048746 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2048752 | — | IC50 | = | 189.3 | nM | 6.72 |
| CHEMBL2048751 | — | IC50 | = | 199.4 | nM | 6.70 |
| CHEMBL2048749 | — | IC50 | = | 361.8 | nM | 6.44 |
| CHEMBL2048755 | — | IC50 | = | 381.1 | nM | 6.42 |