Assay Detail
Binding
CHEMBL2051701
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Inhibition of human recombinant HDAC6 after 30 mins by fluorometric assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.93 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2048746 | — | — | 1 | 9.00 |
| CHEMBL2048749 | — | — | 1 | 8.48 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 8.30 |
| CHEMBL2048752 | — | — | 1 | 7.74 |
| CHEMBL2048755 | — | — | 1 | 7.39 |
| CHEMBL2048750 | — | — | 1 | 7.34 |
| CHEMBL2048751 | — | — | 1 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2048746 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2048749 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2048752 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL2048755 | — | IC50 | = | 40.4 | nM | 7.39 |
| CHEMBL2048750 | — | IC50 | = | 45.4 | nM | 7.34 |
| CHEMBL2048751 | — | IC50 | = | 59.2 | nM | 7.23 |