Assay Detail
Binding
CHEMBL2051716
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminus His6-tagged human kallikrein 6 expressed in baculovirus infected insect sf9 cells using Boc-Phe-Ser-Arg-AMC as substrate by fluorescence analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Virtual Screening and X-ray Crystallography for Human Kallikrein 6 Inhibitors with an Amidinothiophene P1 Group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.39 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2047313 | — | — | 1 | 5.82 |
| CHEMBL2047314 | — | — | 1 | 5.54 |
| CHEMBL435585 | — | — | 1 | 5.11 |
| CHEMBL2047315 | — | — | 1 | 5.09 |
| CHEMBL331939 | — | — | 1 | - |
| CHEMBL331943 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2047313 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2047314 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL435585 | — | IC50 | = | 7750.0 | nM | 5.11 |
| CHEMBL2047315 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL331939 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL331943 | — | IC50 | > | 30000.0 | nM | - |