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Assay Detail

CHEMBL2059949

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Binding
Inhibition of Hepatitis C virus NS5B polymerase
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepatitis C virus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and antiviral properties of novel 7-heterocyclic substituted 7-deaza-adenine nucleoside inhibitors of Hepatitis C NS5B polymerase.
Di Francesco ME, Avolio S, Pompei M, Pesci S, Monteagudo E, Pucci V, Giuliano C, Fiore F, Rowley M, Summa V.
Bioorg Med Chem (2012) 20 : 4801 -4811
PubMed 22770556 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 6.03 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2059134 1 7.16
CHEMBL2059351 1 7.16
CHEMBL2059136 1 7.00
CHEMBL2057532 1 7.00
CHEMBL2058931 1 7.00
CHEMBL2059350 1 6.52
CHEMBL2059133 1 6.52
CHEMBL2059132 1 6.40
CHEMBL2059349 1 6.40
CHEMBL2059139 1 6.30
CHEMBL2059141 1 6.30
CHEMBL2059128 1 6.30
CHEMBL2059130 1 6.30
CHEMBL2058932 1 5.08
CHEMBL2059347 1 5.08
CHEMBL2059140 1 5.08
CHEMBL2059137 1 5.08
CHEMBL2059129 1 5.08
CHEMBL2059131 1 5.08
CHEMBL2059138 1 4.92
CHEMBL2058933 1 4.92
CHEMBL2059135 1 -
CHEMBL2059348 1 -
CHEMBL2057228 1 -
CHEMBL2057529 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2059134 IC50 = 70.0 nM 7.16
CHEMBL2059351 IC50 = 70.0 nM 7.16
CHEMBL2059136 IC50 = 100.0 nM 7.00
CHEMBL2057532 IC50 = 100.0 nM 7.00
CHEMBL2058931 IC50 = 100.0 nM 7.00
CHEMBL2059350 IC50 = 300.0 nM 6.52
CHEMBL2059133 IC50 = 300.0 nM 6.52
CHEMBL2059132 IC50 = 400.0 nM 6.40
CHEMBL2059349 IC50 = 400.0 nM 6.40
CHEMBL2059139 IC50 = 500.0 nM 6.30
CHEMBL2059141 IC50 = 500.0 nM 6.30
CHEMBL2059128 IC50 = 500.0 nM 6.30
CHEMBL2059130 IC50 = 500.0 nM 6.30
CHEMBL2058932 IC50 = 8400.0 nM 5.08
CHEMBL2059347 IC50 = 8400.0 nM 5.08
CHEMBL2059140 IC50 = 8400.0 nM 5.08
CHEMBL2059137 IC50 = 8400.0 nM 5.08
CHEMBL2059129 IC50 = 8400.0 nM 5.08
CHEMBL2059131 IC50 = 8400.0 nM 5.08
CHEMBL2059138 IC50 = 12000.0 nM 4.92
CHEMBL2058933 IC50 = 12000.0 nM 4.92
CHEMBL2059135 IC50 > 100000.0 nM -
CHEMBL2059348 IC50 > 95000.0 nM -
CHEMBL2057228 IC50 > 95000.0 nM -
CHEMBL2057529 IC50 > 100000.0 nM -