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Assay Detail

CHEMBL2060099

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against asexual erythrocyte stage of chloroquine-sensitive Plasmodium falciparum D10 by parasite lactate dehydrogenase assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis, antimalarial activity and cytotoxicity of 10-aminoethylether derivatives of artemisinin.
Cloete TT, Wilma Breytenbach J, Kock Cd, Smith PJ, Breytenbach JC, N'da DD.
Bioorg Med Chem (2012) 20 : 4701 -4709
PubMed 22750008 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 8.48 9.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL307261 ARTENIMOL 3.0 1 9.11
CHEMBL207675 SODIUM ARESUNATE 1 9.03
CHEMBL2058099 1 8.84
CHEMBL2058097 1 8.74
CHEMBL2058102 1 8.74
CHEMBL2058098 1 8.62
CHEMBL2058101 1 8.58
CHEMBL2058095 1 8.48
CHEMBL2058103 1 8.40
CHEMBL2057785 1 8.33
CHEMBL2058100 1 8.22
CHEMBL2058096 1 8.17
CHEMBL2058094 1 8.16
CHEMBL76 CHLOROQUINE 4.0 1 7.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL307261 ARTENIMOL IC50 = 0.785 nM 9.11
CHEMBL207675 SODIUM ARESUNATE IC50 = 0.933 nM 9.03
CHEMBL2058099 IC50 = 1.444 nM 8.84
CHEMBL2058097 IC50 = 1.833 nM 8.74
CHEMBL2058102 IC50 = 1.799 nM 8.74
CHEMBL2058098 IC50 = 2.413 nM 8.62
CHEMBL2058101 IC50 = 2.612 nM 8.58
CHEMBL2058095 IC50 = 3.312 nM 8.48
CHEMBL2058103 IC50 = 4.015 nM 8.40
CHEMBL2057785 IC50 = 4.637 nM 8.33
CHEMBL2058100 IC50 = 6.038 nM 8.22
CHEMBL2058096 IC50 = 6.718 nM 8.17
CHEMBL2058094 IC50 = 6.885 nM 8.16
CHEMBL76 CHLOROQUINE IC50 = 46.64 nM 7.33