Assay Detail
Binding
CHEMBL2060148
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant DPP8 using Gly-Pro-MCA as substrate after 30 mins by fluorometry
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Fused bicyclic heteroarylpiperazine-substituted L-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.53 | 7.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL391466 | — | — | 1 | 7.91 |
| CHEMBL2058971 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL391466 | — | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL2058971 | — | IC50 | = | 72.4 | nM | 7.14 |