Assay Detail
Binding
CHEMBL2060169
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Displacement of [125I]AngII from type 1 angiotensin 2 receptor in bovine adrenal cortex
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Adrenal cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 4'-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamide derivatives as dual angiotensin II/endothelin A receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.75 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2058372 | — | — | 1 | 8.07 |
| CHEMBL2058371 | — | — | 1 | 8.04 |
| CHEMBL2058373 | — | — | 1 | 8.01 |
| CHEMBL2058370 | — | — | 1 | 8.00 |
| CHEMBL2058374 | — | — | 1 | 8.00 |
| CHEMBL2058375 | — | — | 1 | 7.98 |
| CHEMBL2058376 | — | — | 1 | 7.96 |
| CHEMBL2058377 | — | — | 1 | 7.92 |
| CHEMBL2058369 | — | — | 1 | 7.80 |
| CHEMBL2058368 | — | — | 1 | 7.55 |
| CHEMBL2058367 | — | — | 1 | 7.35 |
| CHEMBL2058366 | — | — | 1 | 7.04 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2058372 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL2058371 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL2058373 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL2058370 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL2058374 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2058375 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL2058376 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2058377 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2058369 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2058368 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2058367 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2058366 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL191 | LOSARTAN | IC50 | = | 95.0 | nM | 7.02 |