Assay Detail
Binding
CHEMBL2060804
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG channel expressed in CHO cells by patch clamp assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Imidazolopiperazines: lead optimization of the second-generation antimalarial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.91 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1800137 | — | — | 1 | 5.25 |
| CHEMBL2058833 | GANAPLACIDE | 2.0 | 1 | 4.87 |
| CHEMBL2058831 | — | — | 1 | 4.87 |
| CHEMBL2058837 | — | — | 1 | 4.66 |
| CHEMBL2059066 | — | — | 1 | - |
| CHEMBL2058844 | — | — | 1 | - |
| CHEMBL2058843 | — | — | 1 | - |
| CHEMBL2058842 | — | — | 1 | - |
| CHEMBL2058841 | — | — | 1 | - |
| CHEMBL2058840 | — | — | 1 | - |
| CHEMBL2058838 | — | — | 1 | - |
| CHEMBL2057225 | — | — | 1 | - |
| CHEMBL1800836 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1800137 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL2058833 | GANAPLACIDE | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL2058831 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL2058837 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL2059066 | — | IC50 | - | — | - | |
| CHEMBL2058844 | — | IC50 | - | — | - | |
| CHEMBL2058843 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2058842 | — | IC50 | - | — | - | |
| CHEMBL2058841 | — | IC50 | - | — | - | |
| CHEMBL2058840 | — | IC50 | - | — | - | |
| CHEMBL2058838 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2057225 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1800836 | — | IC50 | - | — | - |