Assay Detail
Binding
CHEMBL2060908
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Binding affinity to Human immunodeficiency virus 1 protease by SPR biosensor interaction analysis at pH 7.4
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Experimental and 'in silico' analysis of the effect of pH on HIV-1 protease inhibitor affinity: implications for the charge state of the protein ionogenic groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 7.96 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | 4.0 | 1 | 9.24 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 8.92 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 8.47 |
| CHEMBL354502 | — | — | 1 | 8.16 |
| CHEMBL105459 | — | — | 1 | 7.97 |
| CHEMBL367384 | — | — | 1 | 7.86 |
| CHEMBL301728 | ACETYLPEPSTATIN | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL114 | SAQUINAVIR | Kd | = | 0.577 | nM | 9.24 |
| CHEMBL5483011 | INDINAVIR | Kd | = | 1.2 | nM | 8.92 |
| CHEMBL584 | NELFINAVIR | Kd | = | 3.4 | nM | 8.47 |
| CHEMBL354502 | — | Kd | = | 6.95 | nM | 8.16 |
| CHEMBL105459 | — | Kd | = | 10.8 | nM | 7.97 |
| CHEMBL367384 | — | Kd | = | 13.9 | nM | 7.86 |
| CHEMBL301728 | ACETYLPEPSTATIN | Kd | = | 8150.0 | nM | 5.09 |