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Assay Detail

CHEMBL2060914

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ADMET
Antiproliferative activity against mouse BALB/3T3 cells after 72 hrs by SRB assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Mus musculus
Cell Type BALB/3T3
Confidence 1 — Organism
Curated By Autocuration

Target

BALB/3T3 (CHEMBL613876)
Type CELL-LINE
Organism Mus musculus

Publication

Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted 5H- and 6H-indolo[2,3-b]quinolines; structure-activity relationships of neocryptolepines and 6-methyl congeners.
Wang L, Switalska M, Mei ZW, Lu WJ, Takahara Y, Feng XW, El-Sayed Iel-T, Wietrzyk J, Inokuchi T.
Bioorg Med Chem (2012) 20 : 4820 -4829
PubMed 22748378 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.77 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2058015 1 6.40
CHEMBL2058006 1 6.20
CHEMBL2058019 1 6.13
CHEMBL2058022 1 6.09
CHEMBL2058021 1 6.07
CHEMBL2058020 1 6.06
CHEMBL2058009 1 6.05
CHEMBL2058008 1 6.03
CHEMBL2058024 1 6.01
CHEMBL359744 DOXORUBICIN HYDROCHLORIDE 4.0 1 5.97
CHEMBL2058017 1 5.92
CHEMBL2058010 1 5.79
CHEMBL2058023 1 5.79
CHEMBL2058013 1 5.19
CHEMBL2058018 1 5.12
CHEMBL2058029 1 5.04
CHEMBL2058030 1 5.01
CHEMBL2057434 1 4.98
CHEMBL2058028 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2058015 IC50 = 401.0 nM 6.40
CHEMBL2058006 IC50 = 635.0 nM 6.20
CHEMBL2058019 IC50 = 742.0 nM 6.13
CHEMBL2058022 IC50 = 807.0 nM 6.09
CHEMBL2058021 IC50 = 853.0 nM 6.07
CHEMBL2058020 IC50 = 869.0 nM 6.06
CHEMBL2058009 IC50 = 884.0 nM 6.05
CHEMBL2058008 IC50 = 936.0 nM 6.03
CHEMBL2058024 IC50 = 978.0 nM 6.01
CHEMBL359744 DOXORUBICIN HYDROCHLORIDE IC50 = 1078.0 nM 5.97
CHEMBL2058017 IC50 = 1197.0 nM 5.92
CHEMBL2058010 IC50 = 1607.0 nM 5.79
CHEMBL2058023 IC50 = 1622.0 nM 5.79
CHEMBL2058013 IC50 = 6413.0 nM 5.19
CHEMBL2058018 IC50 = 7600.0 nM 5.12
CHEMBL2058029 IC50 = 9012.0 nM 5.04
CHEMBL2058030 IC50 = 9798.0 nM 5.01
CHEMBL2057434 IC50 = 10437.0 nM 4.98
CHEMBL2058028 IC50 > 25000.0 nM -