Assay Detail
Binding
CHEMBL2060992
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human nAChR alpha7 expressed in HEK cells coexpressing RIC3
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Diazaspirocyclic compounds as selective ligands for the α4β2 nicotinic acetylcholine receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.12 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL504652 | TC-2216 | 1.0 | 1 | 5.16 |
| CHEMBL2057714 | — | — | 1 | 5.12 |
| CHEMBL2057712 | — | — | 1 | 5.10 |
| CHEMBL2057713 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL504652 | TC-2216 | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL2057714 | — | Ki | = | 7600.0 | nM | 5.12 |
| CHEMBL2057712 | — | Ki | = | 7900.0 | nM | 5.10 |
| CHEMBL2057713 | — | Ki | = | 8000.0 | nM | 5.10 |