Assay Detail
Binding
CHEMBL2061056
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of P-glycoprotein-mediated daunorubicin efflux from human CCRF-CEM/VCR1000 cells after 240 secs by FACS flow cytometric analysis
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.45 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL375243 | — | — | 1 | 8.25 |
| CHEMBL313113 | — | — | 1 | 7.50 |
| CHEMBL348475 | TARIQUIDAR | 3.0 | 1 | 7.48 |
| CHEMBL2059236 | — | — | 1 | 7.30 |
| CHEMBL344278 | — | — | 1 | 7.24 |
| CHEMBL444172 | ZOSUQUIDAR | 3.0 | 1 | 7.23 |
| CHEMBL396298 | ELACRIDAR | 2.0 | 1 | 7.14 |
| CHEMBL2058782 | — | — | 1 | 7.10 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 6.99 |
| CHEMBL148318 | — | — | 1 | 6.82 |
| CHEMBL2058783 | — | — | 1 | 6.77 |
| CHEMBL2059231 | — | — | 1 | 6.70 |
| CHEMBL148260 | — | — | 1 | 6.51 |
| CHEMBL631 | PROPAFENONE | 4.0 | 1 | 6.48 |
| CHEMBL2059235 | — | — | 1 | 6.42 |
| CHEMBL2059234 | — | — | 1 | 6.32 |
| CHEMBL2059232 | — | — | 1 | 6.30 |
| CHEMBL1086218 | VALSPODAR | 3.0 | 1 | 6.30 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 6.24 |
| CHEMBL2058785 | — | — | 1 | 6.24 |
| CHEMBL319952 | — | — | 1 | 6.22 |
| CHEMBL2058784 | — | — | 1 | 6.19 |
| CHEMBL405355 | NIGULDIPINE | 2.0 | 1 | 6.15 |
| CHEMBL2058786 | — | — | 1 | 6.01 |
| CHEMBL2059233 | — | — | 1 | 5.92 |
| CHEMBL2059229 | — | — | 1 | 5.92 |
| CHEMBL1895098 | — | — | 1 | 5.66 |
| CHEMBL2059230 | — | — | 1 | 5.45 |
| CHEMBL1877038 | — | — | 1 | 5.27 |
| CHEMBL2059399 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL375243 | — | IC50 | = | 5.623 | nM | 8.25 |
| CHEMBL313113 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL348475 | TARIQUIDAR | IC50 | = | 33.11 | nM | 7.48 |
| CHEMBL2059236 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL344278 | — | IC50 | = | 57.54 | nM | 7.24 |
| CHEMBL444172 | ZOSUQUIDAR | IC50 | = | 58.88 | nM | 7.23 |
| CHEMBL396298 | ELACRIDAR | IC50 | = | 72.44 | nM | 7.14 |
| CHEMBL2058782 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 102.33 | nM | 6.99 |
| CHEMBL148318 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2058783 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2059231 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL148260 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL631 | PROPAFENONE | IC50 | = | 331.13 | nM | 6.48 |
| CHEMBL2059235 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL2059234 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL2059232 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1086218 | VALSPODAR | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 575.44 | nM | 6.24 |
| CHEMBL2058785 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL319952 | — | IC50 | = | 602.56 | nM | 6.22 |
| CHEMBL2058784 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL405355 | NIGULDIPINE | IC50 | = | 707.95 | nM | 6.15 |
| CHEMBL2058786 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL2059233 | — | IC50 | = | 1210.0 | nM | 5.92 |
| CHEMBL2059229 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1895098 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL2059230 | — | IC50 | = | 3550.0 | nM | 5.45 |
| CHEMBL1877038 | — | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL2059399 | — | IC50 | = | 9480.0 | nM | 5.02 |
| CHEMBL2057229 | — | IC50 | = | 13370.0 | nM | 4.87 |