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Assay Detail

CHEMBL2061097

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant phosphatase activity of Cdc25A catalytic domain expressed in Escherichia coli BL21(DE3) using OMFP as substrate in presence of recombinant superoxide dismutase
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

M-phase inducer phosphatase 1 (CHEMBL3775)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of new inhibitors of Cdc25B dual specificity phosphatases by structure-based virtual screening.
Lavecchia A, Di Giovanni C, Pesapane A, Montuori N, Ragno P, Martucci NM, Masullo M, De Vendittis E, Novellino E.
J Med Chem (2012) 55 : 4142 -4158
PubMed 22524450 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.48 6.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1481974 1 6.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1481974 IC50 = 330.0 nM 6.48