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Assay Detail

CHEMBL2061191

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by Geimsa staining
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: synthesis and pharmacological evaluation.
Ongarora DS, Gut J, Rosenthal PJ, Masimirembwa CM, Chibale K.
Bioorg Med Chem Lett (2012) 22 : 5046 -5050
PubMed 22749280 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 7.18 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1630 1 8.30
CHEMBL2058036 1 8.10
CHEMBL2058034 1 7.96
CHEMBL2057721 1 7.92
CHEMBL2057722 1 7.89
CHEMBL2058040 1 7.68
CHEMBL2058033 1 7.40
CHEMBL2058041 1 7.39
CHEMBL76 CHLOROQUINE 4.0 1 7.31
CHEMBL2058039 1 6.70
CHEMBL2058035 1 6.31
CHEMBL2058037 1 6.30
CHEMBL2057720 1 5.94
CHEMBL2058038 1 5.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1630 IC50 = 5.0 nM 8.30
CHEMBL2058036 IC50 = 8.0 nM 8.10
CHEMBL2058034 IC50 = 11.0 nM 7.96
CHEMBL2057721 IC50 = 12.0 nM 7.92
CHEMBL2057722 IC50 = 13.0 nM 7.89
CHEMBL2058040 IC50 = 21.0 nM 7.68
CHEMBL2058033 IC50 = 40.0 nM 7.40
CHEMBL2058041 IC50 = 41.0 nM 7.39
CHEMBL76 CHLOROQUINE IC50 = 49.0 nM 7.31
CHEMBL2058039 IC50 = 200.0 nM 6.70
CHEMBL2058035 IC50 = 491.0 nM 6.31
CHEMBL2058037 IC50 = 501.0 nM 6.30
CHEMBL2057720 IC50 = 1158.0 nM 5.94
CHEMBL2058038 IC50 = 4580.0 nM 5.34