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Assay Detail

CHEMBL2061419

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of CDK2/cyclin E
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Cyclin-dependent kinase 2/cyclin E1 (CHEMBL1907605)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Synthesis, biological evaluation, and molecular docking studies of N-((1,3-diphenyl-1H-pyrazol-4-yl)methyl)aniline derivatives as novel anticancer agents.
Huang XF, Lu X, Zhang Y, Song GQ, He QL, Li QS, Yang XH, Wei Y, Zhu HL.
Bioorg Med Chem (2012) 20 : 4895 -4900
PubMed 22819191 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.52 6.01

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2057879 1 6.01
CHEMBL2057880 1 5.93
CHEMBL2057881 1 5.73
CHEMBL2057882 1 5.68
CHEMBL2057883 1 5.63
CHEMBL2057884 1 5.59
CHEMBL2057885 1 5.56
CHEMBL2057886 1 5.52
CHEMBL2057887 1 5.44
CHEMBL2057888 1 5.41
CHEMBL2057891 1 5.40
CHEMBL2057889 1 5.38
CHEMBL2058160 1 5.37
CHEMBL2057890 1 5.34
CHEMBL2058161 1 5.30
CHEMBL2058162 1 5.30
CHEMBL280074 OLOMOUCINE 1 5.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2057879 IC50 = 980.0 nM 6.01
CHEMBL2057880 IC50 = 1180.0 nM 5.93
CHEMBL2057881 IC50 = 1850.0 nM 5.73
CHEMBL2057882 IC50 = 2080.0 nM 5.68
CHEMBL2057883 IC50 = 2360.0 nM 5.63
CHEMBL2057884 IC50 = 2560.0 nM 5.59
CHEMBL2057885 IC50 = 2780.0 nM 5.56
CHEMBL2057886 IC50 = 3020.0 nM 5.52
CHEMBL2057887 IC50 = 3600.0 nM 5.44
CHEMBL2057888 IC50 = 3890.0 nM 5.41
CHEMBL2057891 IC50 = 4020.0 nM 5.40
CHEMBL2057889 IC50 = 4150.0 nM 5.38
CHEMBL2058160 IC50 = 4280.0 nM 5.37
CHEMBL2057890 IC50 = 4550.0 nM 5.34
CHEMBL2058161 IC50 = 4960.0 nM 5.30
CHEMBL2058162 IC50 = 5060.0 nM 5.30
CHEMBL280074 OLOMOUCINE IC50 = 5000.0 nM 5.30