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Assay Detail

CHEMBL2061532

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Functional
Antiproliferative activity against human COLO205 cells by MTT assay
16
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type COLO 205
Confidence 1 — Organism
Curated By Autocuration

Target

COLO 205 (CHEMBL614561)
Type CELL-LINE
Organism Homo sapiens

Publication

InCl3-catalysed synthesis of 2-aryl quinazolin-4(3H)-ones and 5-aryl pyrazolo[4,3-d]pyrimidin-7(6H)-ones and their evaluation as potential anticancer agents.
Mulakayala N, Kandagatla B, Ismail, Rapolu RK, Rao P, Mulakayala C, Kumar CS, Iqbal J, Oruganti S.
Bioorg Med Chem Lett (2012) 22 : 5063 -5066
PubMed 22749421 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.94 5.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2058065 1 5.16
CHEMBL336718 1 5.10
CHEMBL269538 HARMINE 1.0 1 5.10
CHEMBL2058061 1 5.05
CHEMBL18688 1 5.00
CHEMBL2058058 1 5.00
CHEMBL2058064 1 5.00
CHEMBL2058057 1 4.96
CHEMBL2058060 1 4.96
CHEMBL2058056 1 4.92
CHEMBL1164165 2 4.92
CHEMBL2058063 1 4.92
CHEMBL127066 1 4.89
CHEMBL2058062 1 4.85
CHEMBL2058059 1 4.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2058065 IC50 = 7000.0 nM 5.16
CHEMBL336718 IC50 = 8000.0 nM 5.10
CHEMBL269538 HARMINE IC50 = 8000.0 nM 5.10
CHEMBL2058061 IC50 = 9000.0 nM 5.05
CHEMBL18688 IC50 = 10000.0 nM 5.00
CHEMBL2058058 IC50 = 10000.0 nM 5.00
CHEMBL2058064 IC50 = 10000.0 nM 5.00
CHEMBL2058057 IC50 = 11000.0 nM 4.96
CHEMBL2058060 IC50 = 11000.0 nM 4.96
CHEMBL2058056 IC50 = 12000.0 nM 4.92
CHEMBL1164165 IC50 = 12000.0 nM 4.92
CHEMBL2058063 IC50 = 12000.0 nM 4.92
CHEMBL127066 IC50 = 13000.0 nM 4.89
CHEMBL2058062 IC50 = 14000.0 nM 4.85
CHEMBL1164165 IC50 = 23000.0 nM 4.64
CHEMBL2058059 IC50 = 25000.0 nM 4.60