Assay Detail
Binding
CHEMBL2061902
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Inhibition of G6PD in HEK293T cells assessed as accumulation of 6-phosphogluconate after 5 hrs by LC-MS/MS analysis using 6-aminonicotinamide
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel steroid inhibitors of glucose 6-phosphate dehydrogenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.90 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2057307 | — | — | 1 | 5.32 |
| CHEMBL2057296 | — | — | 1 | 5.11 |
| CHEMBL2057310 | — | — | 1 | 5.04 |
| CHEMBL2057293 | — | — | 1 | 5.02 |
| CHEMBL2057971 | — | — | 1 | 4.91 |
| CHEMBL2057640 | — | — | 1 | 4.85 |
| CHEMBL2057300 | — | — | 1 | 4.76 |
| CHEMBL90593 | PRASTERONE | 4.0 | 1 | 4.60 |
| CHEMBL2057318 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2057307 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2057296 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL2057310 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL2057293 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL2057971 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL2057640 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL2057300 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL90593 | PRASTERONE | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL2057318 | — | IC50 | = | 35200.0 | nM | 4.45 |