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Assay Detail

CHEMBL2064930

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Erk2 in presence of 10 uM ATP
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase 1 (CHEMBL4040)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors.
Ji Z, Dai Y, Abad-Zapatero C, Albert DH, Bouska JJ, Glaser KB, Marcotte PA, Soni NB, Magoc TJ, Stewart KD, Wei RQ, Davidsen SK, Michaelides MR.
Bioorg Med Chem Lett (2012) 22 : 4528 -4531
PubMed 22727637 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.53 6.53

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1990583 1 6.53

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1990583 IC50 = 296.0 nM 6.53