Assay Detail
Binding
CHEMBL2065329
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DTG from sigma2 receptor in Sprague-Dawley rat liver membrane after 90 mins by liquid scintillation counting in presence of pentazocine
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Syntheses and in vitro evaluation of decalinvesamicol analogues as potential imaging probes for vesicular acetylcholine transporter (VAChT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.93 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.50 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.29 |
| CHEMBL2064617 | — | — | 1 | 7.17 |
| CHEMBL20943 | — | — | 1 | 7.06 |
| CHEMBL2064615 | — | — | 1 | 6.92 |
| CHEMBL2064616 | — | — | 1 | 6.86 |
| CHEMBL60542 | (+)-PENTAZOCINE | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 31.7 | nM | 7.50 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 51.6 | nM | 7.29 |
| CHEMBL2064617 | — | Ki | = | 68.3 | nM | 7.17 |
| CHEMBL20943 | — | Ki | = | 86.7 | nM | 7.06 |
| CHEMBL2064615 | — | Ki | = | 118.8 | nM | 6.92 |
| CHEMBL2064616 | — | Ki | = | 137.5 | nM | 6.86 |
| CHEMBL60542 | (+)-PENTAZOCINE | Ki | = | 1880.8 | nM | 5.73 |