Assay Detail
Binding
CHEMBL2065441
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Inhibition of CK2alpha in human HCT116 cells assessed as decrease in AKT phosphorylation at S129 residue after 3 to 24 hrs by Western blot analysis
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.59 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2062580 | — | — | 1 | 7.57 |
| CHEMBL2062577 | — | — | 1 | 7.47 |
| CHEMBL2062571 | — | — | 1 | 7.24 |
| CHEMBL2062581 | — | — | 1 | 7.11 |
| CHEMBL2062579 | — | — | 1 | 7.08 |
| CHEMBL2062572 | — | — | 1 | 6.72 |
| CHEMBL2062583 | — | — | 1 | 6.68 |
| CHEMBL2062573 | — | — | 1 | 6.34 |
| CHEMBL2062582 | — | — | 1 | 6.30 |
| CHEMBL2062574 | — | — | 1 | 6.11 |
| CHEMBL2062578 | — | — | 1 | 6.08 |
| CHEMBL2062576 | — | — | 1 | 6.07 |
| CHEMBL2062575 | — | — | 1 | 5.92 |
| CHEMBL2062585 | — | — | 1 | 5.51 |
| CHEMBL2062584 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2062580 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2062577 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL2062571 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL2062581 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL2062579 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL2062572 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2062583 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2062573 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL2062582 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2062574 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL2062578 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL2062576 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL2062575 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2062585 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL2062584 | — | IC50 | - | — | - |