Assay Detail
Binding
CHEMBL2065550
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-CGRP from CGRP receptor in human SK-N-MC cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Calcitonin gene-related peptide type 1 receptor (CHEMBL3798) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of Migraine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.33 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207197 | OLCEGEPANT | 2.0 | 1 | 11.00 |
| CHEMBL2023191 | — | — | 1 | 10.15 |
| CHEMBL2063115 | — | — | 1 | 10.15 |
| CHEMBL2063116 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207197 | OLCEGEPANT | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL2023191 | — | Ki | = | 0.071 | nM | 10.15 |
| CHEMBL2063115 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL2063116 | — | Ki | = | 940.0 | nM | 6.03 |