Assay Detail
Binding
CHEMBL2065752
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Clostridium botulinum Hall BoNT/A protease activity using Ac-SNKTRIDEANQRATKML-NH2 as substrate after 5 mins by RP-HPLC analysis
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Clostridium botulinum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Botulinum neurotoxin type A (CHEMBL5344) ↗| Type | SINGLE PROTEIN |
| Organism | Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) |
Publication
Fungal bis-Naphthopyrones as Inhibitors of Botulinum Neurotoxin Serotype A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.90 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL599255 | — | — | 1 | 5.68 |
| CHEMBL2062928 | TALARODERXINE A | — | 2 | 5.43 |
| CHEMBL1099258 | CHAETOCHROMIN A | — | 1 | 4.61 |
| CHEMBL500027 | SECALONIC ACID A | — | 1 | 4.54 |
| CHEMBL463175 | CEPHALOCHROMIN | — | 1 | 4.54 |
| CHEMBL472851 | SKYRIN | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL599255 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2062928 | TALARODERXINE A | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL2062928 | TALARODERXINE A | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL1099258 | CHAETOCHROMIN A | IC50 | = | 24600.0 | nM | 4.61 |
| CHEMBL500027 | SECALONIC ACID A | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL463175 | CEPHALOCHROMIN | IC50 | = | 29200.0 | nM | 4.54 |
| CHEMBL472851 | SKYRIN | IC50 | = | 31500.0 | nM | 4.50 |