Assay Detail
Binding
CHEMBL2065772
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of human MMP3 using fluorogenic substrate by Dixon plot analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship for Thiirane-Based Gelatinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.20 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1651842 | — | — | 1 | 6.24 |
| CHEMBL2063274 | — | — | 1 | 5.66 |
| CHEMBL2063273 | — | — | 1 | 5.39 |
| CHEMBL2063276 | — | — | 1 | 4.92 |
| CHEMBL483857 | — | — | 1 | 4.82 |
| CHEMBL2063275 | — | — | 1 | 4.77 |
| CHEMBL2063271 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1651842 | — | Ki | = | 575.0 | nM | 6.24 |
| CHEMBL2063274 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL2063273 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL2063276 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL483857 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL2063275 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL2063271 | — | Ki | = | 27000.0 | nM | 4.57 |