Assay Detail
Binding
CHEMBL2065781
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Competitive inhibition of human MMP14 using fluorogenic substrate by Dixon plot analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship for Thiirane-Based Gelatinase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.63 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483857 | — | — | 1 | 7.43 |
| CHEMBL2063274 | — | — | 1 | 7.05 |
| CHEMBL2063276 | — | — | 1 | 6.85 |
| CHEMBL1651842 | — | — | 1 | 6.84 |
| CHEMBL2063271 | — | — | 1 | 6.72 |
| CHEMBL2063273 | — | — | 1 | 6.67 |
| CHEMBL2063275 | — | — | 1 | 6.55 |
| CHEMBL2063270 | — | — | 1 | 6.24 |
| CHEMBL2063277 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483857 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL2063274 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL2063276 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL1651842 | — | Ki | = | 145.0 | nM | 6.84 |
| CHEMBL2063271 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL2063273 | — | Ki | = | 215.0 | nM | 6.67 |
| CHEMBL2063275 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL2063270 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL2063277 | — | Ki | = | 5080.0 | nM | 5.29 |