Assay Detail
Functional
CHEMBL2065817
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Antileishmanial activity against intracellular Leishmania amazonensis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania amazonensis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, DNA binding and antileishmanial activity of low molecular weight bis-arylimidamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.24 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1275764 | — | — | 1 | 7.06 |
| CHEMBL3216564 | — | — | 1 | 6.85 |
| CHEMBL3217216 | — | — | 1 | 6.17 |
| CHEMBL3217009 | — | — | 1 | 6.12 |
| CHEMBL3216786 | — | — | 1 | 5.96 |
| CHEMBL3216562 | — | — | 1 | 5.29 |
| CHEMBL3215673 | — | — | 1 | - |
| CHEMBL3216561 | — | — | 1 | - |
| CHEMBL3216324 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1275764 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL3216564 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3217216 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL3217009 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL3216786 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3216562 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL3215673 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3216561 | — | IC50 | - | — | - | |
| CHEMBL3216324 | — | IC50 | > | 10000.0 | nM | - |