Assay Detail
Binding
CHEMBL2065864
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Inhibition of His6-tagged Plasmodium falciparum DXR expressed in Escherichia coli M15 using DXP as substrate preincubated for 5 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Thermodynamic Investigation of Inhibitor Binding to 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.62 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL205338 | FR-900098 | — | 1 | 7.96 |
| CHEMBL204106 | — | — | 1 | 7.82 |
| CHEMBL203125 | FOSMIDOMYCIN | 3.0 | 1 | 7.68 |
| CHEMBL1615246 | — | — | 1 | 5.96 |
| CHEMBL1615245 | PYRIDIN-2-YLMETHYLPHOSPHONIC ACID | — | 1 | 5.48 |
| CHEMBL574580 | 1-HYDROXY-5-PHENYLPYRIDIN-2(1H)-ONE | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL205338 | FR-900098 | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL204106 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL203125 | FOSMIDOMYCIN | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL1615246 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL1615245 | PYRIDIN-2-YLMETHYLPHOSPHONIC ACID | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL574580 | 1-HYDROXY-5-PHENYLPYRIDIN-2(1H)-ONE | Ki | = | 14600.0 | nM | 4.84 |