Assay Detail
Binding
CHEMBL2066293
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Inhibition of LPS-stimulated NFkappaB activation transfected in mouse RAW264.7 cells after 18 hrs by luciferase reporter gene assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | RAW264.7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as potent immune modulating agents by scrutiny of LC-MS/ELSD libraries.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.23 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256279 | BENGAMIDE A | — | 1 | 7.12 |
| CHEMBL446079 | BENGAMIDE B | — | 1 | 7.07 |
| CHEMBL301982 | CELASTROL | — | 1 | 6.70 |
| CHEMBL2063315 | — | — | 1 | 6.30 |
| CHEMBL492191 | BENGAMIDE F | — | 1 | 6.16 |
| CHEMBL2063316 | — | — | 1 | 5.70 |
| CHEMBL2063317 | — | — | 1 | 5.70 |
| CHEMBL376628 | BENGAMIDE E | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256279 | BENGAMIDE A | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL446079 | BENGAMIDE B | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL301982 | CELASTROL | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2063315 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL492191 | BENGAMIDE F | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2063316 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2063317 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL376628 | BENGAMIDE E | IC50 | = | 7500.0 | nM | 5.12 |