Assay Detail
Binding
CHEMBL2066303
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of wild type FLT3
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein kinase FLT3 (CHEMBL1974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.66 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2063336 | — | — | 1 | 8.40 |
| CHEMBL2063337 | — | — | 1 | 8.30 |
| CHEMBL2063323 | — | — | 1 | 8.22 |
| CHEMBL2063319 | — | — | 1 | 8.15 |
| CHEMBL2063325 | — | — | 1 | 8.15 |
| CHEMBL2063324 | — | — | 1 | 8.00 |
| CHEMBL2063338 | — | — | 1 | 8.00 |
| CHEMBL2063318 | — | — | 1 | 7.92 |
| CHEMBL2063328 | — | — | 1 | 7.85 |
| CHEMBL2063321 | — | — | 1 | 7.80 |
| CHEMBL2063436 | — | — | 1 | 7.77 |
| CHEMBL2063322 | — | — | 1 | 7.77 |
| CHEMBL2063326 | — | — | 1 | 7.77 |
| CHEMBL2063335 | — | — | 1 | 7.75 |
| CHEMBL2063327 | — | — | 1 | 7.72 |
| CHEMBL223360 | LINIFANIB | 3.0 | 1 | 7.70 |
| CHEMBL2063330 | — | — | 1 | 7.70 |
| CHEMBL2063434 | — | — | 1 | 7.68 |
| CHEMBL2063331 | — | — | 1 | 7.57 |
| CHEMBL2063329 | — | — | 1 | 7.46 |
| CHEMBL2063320 | — | — | 1 | 7.40 |
| CHEMBL2063332 | — | — | 1 | 7.37 |
| CHEMBL2063333 | — | — | 1 | 7.28 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.27 |
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | 7.16 |
| CHEMBL2063435 | — | — | 1 | 7.14 |
| CHEMBL2063334 | — | — | 1 | 6.85 |
| CHEMBL1807466 | — | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2063336 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2063337 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2063323 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL2063319 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2063325 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL2063324 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2063338 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2063318 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2063328 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2063321 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2063436 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2063322 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2063326 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2063335 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2063327 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL223360 | LINIFANIB | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2063330 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2063434 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2063331 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2063329 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL2063320 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2063332 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2063333 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL576982 | QUIZARTINIB | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL2063435 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL2063334 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1807466 | — | IC50 | = | 590.0 | nM | 6.23 |